HYALUAMIN®
KEY STRENGTHS
ACTION ON THE PATHOGENESIS OF KNEE OA
Mechanism of action
HYALUAMIN® Strong acts on two levels:
Level 1
Immediate Lubrication (days)
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Hyaluronic acid restores synovial visco-elasticity
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Reduces joint friction coefficient
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Rapid symptomatic relief
Level 2
Cartilage Regeneration (weeks–months)
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Glycine stimulates type II collagen synthesis (>100% vs. control in vitro)
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Amino acids promote chondrocyte neosynthesis
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Inflammatory modulation (IL-1, TNF-α reduction)
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Cartilage matrix protection
Patented Professional Derma formula:
combines hyaluronic acid (3.2% – double molecular weight, high and low) and seven pro-collagen amino acids (Glycine, L-Proline, L-Lysine, L-Leucine, L-Valine, L-Alanine, Arginine)
Clinically demonstrated joint regeneration:
promotes new collagen synthesis, increases chondrocyte proliferation, and provides cartilage protection by modulating inflammatory processes
Rapid & long-lasting results:
significant pain reduction evident by 3 months and sustained at 6 months, with measurable cartilage thickness increase and improved joint function
Dual visco-inductive and regenerative action:
prolonged lubricating effect and reparative stimulation of joint structures, associated with an average pain reduction of 7172% for up to 6 months
High safety and tolerability:
suitable for long-term maintenance protocols; supplied in a prefilled syringe ready for use
ADDITIONAL BENEFIT OF AMINO ACID (AA) SUPPLEMENTATION THERAPY
FIBROBLAST DENSITY
(Number of cells / 1000 µm²)
INCREASE IN CARTILAGE THICKNESS ASSESSED BY ULTRASOUND EVALUATION
Medial basal cartilage thickness
REDUCTION​ SIGNIFICANT OF PAIN AND IMPROVEMENT OF THE SYMPTOMS CLINICIANS
Corsetti G, D’Antona G, Dioguardi FS, Rezzani R. Topical application of dressing with amino acids improves cutaneous wound healing in aged rats.
Acta Histochem 2010;112(5):497-507
Significant improvement in clinical symptoms was observed after 3 months and maintained at 6 months. Significant reduction in pain at 3 and 6 months, resulting in improved patient quality of life.
16 PATIENTS WITH KNEE OSTEOARTHRITIS (OA)
Patients were evaluated according to the Kellgren–Lawrence classification and treated with Hyaluamin Strong.
ULTRASOUND-GUIDED INTRA-ARTICULAR INJECTION
Administered on a weekly basis for 5 consecutive weeks.
PATIENTS WERE EVALUATED AT 3 AND 6 MONTHS
As specified by the study protocol.
EVALUATED CRITERIA
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Pain intensity (VAS)
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Articular cartilage thickness