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HYALUAMIN®

CLINICAL EVIDENCE

& SCIENTIFIC FOUNDATIONS

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Study 1 – 74 Patients

(DR. MICHAEL JOHN)

Study Objective
 

Evaluate clinical efficacy, safety, and patient satisfaction in knee osteoarthritis treatment with HYALUAMIN® Strong.

Source and Methodology
 

  • Dr. Michael John – Deutsche Zeitschrift für Sportmedizin

  • 74 adults with mild to moderate knee osteoarthritis

  • Evaluation at 30 days post-treatment

Key Results
 

  • Pain reduced by 82.7% (VAS 7.5 → 1.3)

  • Range of Motion improved by 40.6%

  • Medications drastically reduced: 92% → 5.3% of patients

  • 100% of patients would recommend the treatment

  • ZERO serious adverse events

Study 2 – 16 Patients

(PROFESSIONAL DERMA)

Study Objective

 Evaluate structural cartilage regeneration through ultrasound assessment and mid-term clinical efficacy.

Source and Methodology
 

  • Professional Derma SA – Internal study

  • 16 adults with mild to moderate knee osteoarthritis

  • 6-month follow-up with ultrasound evaluation of cartilage thickness

Key Results
 

  • Pain reduced by 71% (VAS 58.0 → 16.2)

  • Quality of life improved by 78% (WOMAC 55.0 → 12.0)

  • Cartilage regenerated by 14.1% (medial thickness: 0.13 → 0.15 mm) – proven by ultrasound

  • ZERO serious adverse events

Ongoing Study 3

(PROFESSIONAL DERMA)

Expansion of Clinical Research
 
Dr. Michael John continues the clinical study with expanded new follow-up:
 

  • Population: Study of 50 patients ongoing

  • Conducted by: Dr. Michael John – Deutsche Zeitschrift für Sportmedizin

  • Objectives:

    • Confirm efficacy and cartilage regeneration on larger sample

    • Evaluate result maintenance beyond 6 months

    • Collect long-term safety data

    • Optimize re-treatment protocols

Timeline
 

  • Study in progress with rigorous methodology

  • Expected results during 2026–2027

Scientific References and Orthobiologic Rationale
 

GLYCINE AND COLLAGEN SYNTHESIS

  • de Paz-Lugo et al., Amino Acids 2018
    Glycine stimulates type II collagen synthesis >100% vs. control in articular chondrocytes

  • Meléndez-Hevia et al., Journal of Biosciences 2009
    Endogenous glycine production insufficient for collagen demand → Justifies localized supplementation in OA patients
     

AMINO ACID MECHANISMS

  • Zhong et al., Current Opinion in Clinical Nutrition 2003
    L-glycine: anti-inflammatory, immunomodulatory, and cytoprotective properties

  • Park et al., Arthritis Research & Therapy 2007
    Nutritional cocktail of amino acids prevents degenerative cartilage progression (rabbit model)

  • Corsetti et al., Acta Histochemica 2010
    Amino acids + hyaluronic acid accelerate tissue regeneration and increase fibroblast proliferation

  • HYALUAMIN® Strong is based on coherent scientific evidence from OA pathophysiology to clinical efficacy

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